RAB0010
Sigma-Aldrich

Angiotensin II EIA Kit

Nacres: NA.32
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Properties

Properties
assay range inter-assay cv: <
astm d 2162 15%
intra-assay cv: <
astm d 301-56 10%
sensitivity: 2.62 
astm d 3835 pg/mL
standard curve range: 0.1-1000 
atc range ng/mL
Description Angiotensin II EIA Kit for serum, plasma, culture supernatant and cell lysates
device size colorimetric
gloss human ... AGT(183)
insert volume sample type culture supernatant(s)
sample type plasma
sample type cell lysate
sample type serum
MDM Code RAB0010-1KT
Material Number RAB0010
Business Unit 34
CAS Number 0

Description

Application

Angiotensin II EIA Kit has been used for quantitative estimation of serum angiotensin-II.

Biochem/physiol Actions

Study on in vitro model shows that mechanical stretch induced Ang II release plays a vital role in mediating stretch-induced hypertrophic response. Ang II is implicated in maintaining blood pressure and has an important role in hypertension and in the pathophysiology of cardiovascular disorders. Ang II also has an essential role in growth induction, cell migration and mitosis of vascular smooth muscle cells. It enhances the production of collagen type I and III in fibroblasts, that results in thickening of the vascular wall and myocardium, and fibrosis. Variation in Ang II gene increases the risk of myocardial infarction, hypertension and left ventricular hypertrophy. Ang II expression is associated with heart failure, cardiac remodeling, diabetes, and the proliferative and inflammatory responses to arterial injury. The pharmacological agents such as angiotensin II-converting enzyme inhibitors or angiotensin II receptor antagonists can be used for treating Ang II-induced hypertension and congestive heart failure.

General description

The Angiotensin II Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting Angiotensin II peptide based on the principle of Competitive Enzyme Immunoassay. EIA-ANGII-1 can theoretically detect all active angiotensins, including ANGI, ANGII, ANGIII and ANGIV. However, it does not detect inactive angiotensinogen.

Immunogen

Angiotensin II, synthetic peptide

SAFETY INFORMATION

Signal Word

Warning

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Flash Point (C)

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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