H6132
Sigma-Aldrich

DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate

Empform:

C27H42N7Na2O20P3S · xH2O

Synonyms English:

HMG-CoA

Nacres: NA.51
Fw: 955.62 (anhydrous basis)
Pubchem Substance Id: 24895729
CAS Number: 103476-21-7
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Properties

Properties
assay
assay range 90% (HPLC)
Description DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate >=90% (HPLC)
inchi key 1S/C27H44N7O20P3S.2Na.H2O/c1-26(221(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(342)8-16(36)37)11-51-57(4849)54-56(4647)50-10-14-20(53-55(4344)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34
inlet and outlet diam. /h12-1419-212539-4042H4-11H21-3H3(H2935)(H3041)(H3637)(H4647)(H4849)(H2283132)(H2434445)
inlet cga 1H2/q
inlet connection diam. 2*+1
inlet connection size /p-2/t14-19-20-21-25-27?
inlet nptf /m1.../s1
inlet o.d. QGWMCHPRNDWWMT-UAUHQYJPSA-L
MDM Code H6132-10MG
Material Number H6132
Business Unit 760
Shipping Mode AP
MRP Type PD
Local HS Code 29349990
EUD NO
Legacy SIGMA
Shelf Life 0
Plant 6311
Sales Org 6304
EUD Documents Needed 0
CAS Number 103476-21-7

Description

Application

DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate has been used in drug treatment to study its effect on mTORC1 regulation. It has also been used to compare the acylomes of two reactive acyl-CoA species, like HMG-CoA and glutaryl-CoA.

Biochem/physiol Actions

DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) is a substrate used to study the specificity and kinetics of the enzyme 3-hydroxyl-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase. HMG-CoA is the key intermediate in the biosynthsis of terpenes and ketone bodies. Its metabolism is the target of statin drugs used to control cholesterol levels.

General description

DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) 

Immunogen

is obtained from acetyl-CoA 

Linkage

acetoacetyl-CoA during condensation with the help of HMG-CoA synthase.

SAFETY INFORMATION

Signal Word

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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