A2942
Sigma-Aldrich

Amphotericin B solution

Empform:

C47H73NO17

Nacres: NA.76
Mdl No: MFCD00877763
Fw: 924.08
Pubchem Substance Id: 24890711
CAS Number: 1397-89-3
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Properties

Properties
antibiotic activity spectrum fungi
concentration 250 
concentricity μ
concentricity × camber g/mL in deionized water
Description Amphotericin B solution 250 mug/mL in deionized water, 0.1 mum filtered, BioReagent, suitable for cell culture
fragrance allergen liquid
indiff. to chromic acid 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(6165-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-1827-3840-444649-5456-5861H19-2648H21-4H3(H5960)/b6-5+9-7+10-8+13-11+14-12+17-15+18-16+/t27-28-29-30+31+32+33-34-35+36+37-38-40+41-42+43+44-46-47+/m0/s1
inherent viscosity APKFDSVGJQXUKY-INPOYWNPSA-N
MDM Code A2942-100ML
Material Number A2942
Business Unit 694
CAS Number 1397-89-3

Description

Application

Amphotericin B solution has been used:
  • as an intraperitoneal injection for the treatment of Aspergillus fumigatus infection in mice
  • as a constituent of aspiration medium for the culture of Chinese Merino ewe ovaries
  • as a constituent of transport medium during the collection of equine corpora lutea
  • as a supplement in RPMI medium for the culture of the mouse-mouse B cell hybridoma 55-6 cell line

Biochem/physiol Actions

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. that is clinically used to treat systemic fungal infections. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.

Caution

Amphotericin B remains active for 3 days in culture at 37°C.

General description

Amphotericin B is a macrocyclic lactone with a hydrophilic polyhydroxyl chain and a lipophilic polyene based hydrocarbon chain.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

Packaging

20,50,100ml

Preparation Note

It is not unusual for this material to form a precipitate in aqueous solutions. Mixing the solution will redissolve most of the precipitate but, if it does not fully resolubilize, the Amphotericin B will still be suitable for use.

SAFETY INFORMATION

Signal Word

RIDADRRIDADR

WGK Germany

WGK 1

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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