646547
Supelco

Tris(2-carboxyethyl)phosphine hydrochloride solution

Empform:

C9H15O6P · HCl

Synonyms English:

TCEP

Nacres: NA.25
Mdl No: MFCD00145469
Fw: 286.65
Pubchem Substance Id: 24883469
CAS Number: 51805-45-9
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Properties

Properties
Description Tris(2-carboxyethyl)phosphine hydrochloride solution 0.5 M, pH 7.0(aqueous solution; pH was adjusted with ammonium hydroxide)
MDM Code 646547-10X1ML
Material Number 646547
Business Unit 524
Shipping Mode AP
CAS Number 51805-45-9

Description

Application

Tris (2-carboxyethyl) phosphine (TCEP) can be used in several downstream applications including SDS-PAGE, mass spectrometry, labeling with cysteine specific tags, and modification of cysteine containing compounds. It prevents oxidation of protein samples, which makes it a useful buffer component as it helps to preserve enzymatic activity. It has been used in the reduction and measurement of glutathione.

Biochem/physiol Actions

As a non-mercaptan reducing agent, it avoids the toxicity inherent in thiol-containing compounds. It is capable of disrupting the botulinum neurotoxin B heavy-chain/light-chain complex that is held together by a single disulfide bond, and that is responsible for endocytosis, and ultimately the toxicity, of the toxin. Since disulfide-coupled subunits are characteristic of many toxins (e.g., ricin, snake venom, and all BoNT serotypes), it may be useful as a rescue prophylactic in cases of toxin administration.

General description

It belongs to the trialkylphosphine class.

SAFETY INFORMATION

Signal Word

Warning

H315 - H319 - H335

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

RIDADRRIDADR

WGK Germany

WGK 1

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Respiratory system

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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